The Reva Clinic News

22 Jan 2014 Date Holder

Detoxification and CYP450 – At The Heart of Health

Green Smoothie

I’m sure many of you have thought of detoxing this January – maybe you’ve tried juicing, fasting or even colonic irrigation in a bid to feel healthy again after the Christmas excess.  But do you know what you’re doing with these detox solutions and why you’re doing it?  This is where the confusing letters come in - specifically the group of CYP450 enzymes…

Detoxification is a vital part of our daily lives whether we know it’s happening or not.  Just during the normal day our body is breaking down substances, hormones, toxins, ready to eliminate them from the body.  Naturally if we go putting in tons of other toxins (alcohol, pesticides, sugar, medicines etc) then we add to the work our detoxification system has to do.  Hence the word detoxification generally crops up in January!  Stress in fact also causes the detoxification system to work harder as it produces lots more chemicals that have to be broken down. 

Detoxification happens in three-phases.  Think of rubbish – we bag up the rubbish and leave it for the dustmen.  The dustman come along and pick up the rubbish, and then they dispose of it.  This is basically the same thing in humans.  The first phase of detoxification relies on a group of enzymes known as CYP450.  These are the ‘baggers’.  They convert toxins into substances ready for elimination – however these converted substances can still be quite toxic unless they’re removed quickly.  Phase 2 enzymes then come along and pick up the rubbish, taking it to be excreted in phase 3, either by the kidneys in the urine, via our faeces or through our sweat.

Lots of research shows us that these different phases and enzymes lie at the heart of our health and wellbeing.  We need them working well to get rid of environmental toxins and process excess hormones, vitamins, drugs and inflammatory molecules.  Poor detoxification capacity is linked to everything from fatigue and muscle aches, to auto-immune conditions and skin problems.  Also diseases like cancer and cardiovascular disease have been linked to detoxification problems. 

Some people have a much higher susceptibility to suffer detoxification problems as the genes that make their enzymes either are not present, or they show variations in how well they work.  DNA analysis is very useful to work out which people have more susceptibility to certain diseases and therefore which people need the greatest support from nutritional and other herbal supplements in order to function at their peak.

Take home tips:

-       The phases of detoxification rely heavily on vitamins and minerals that we get from fruit and vegetables in order to function properly.  Aim to increase your intake via a green smoothie – things to add in: avocado, cucumber, celery, lemon, an apple, ginger, watercress, spinach.  Blend with water or coconut milk and enjoy for breakie!

-       Eating organic wherever possible is important as pesticides and fertilisers add a further toxic load. 

-       Avoiding processed foods and smoked foods help to reduce the burden on the detoxification system.

-       Let me know if you’re interested in a DNA test to determine your risk and susceptibility for detoxification issues.  For people struggling with a health condition we’ve found these insights to be invaluable.  You can always find me on our clinic line 020 7407 9910 or on our Facebook page


NB: Next week we will be continuing the topic of detoxification by focusing on the role of methylation…don’t be scared by the technical sounding name, I’ll keep it simple I promise!